P1119

         Physiol Bohemoslov 1975;24(3):263-8

        Carrageenin-induced experimental pneumonia in rats.

        Wachtlová M, Chválová M, Holuša R, Paleček F.

        The authors verified the possibility of modelling pneumonia by the

        intratracheal administration of carrageenin solution into the lungs of

        rats. The most satisfactory dose was found to be 0.5 ml 0.7% carrageenin

        solution administered at 40 degrees C. The disease, evaluated by the

        morphological and functional signs, culminated after two days. Both

        macroscopically and histologically the lungs displayed typical signs of

        catarrhal suppurative aspiration bronchopneumonia. Functionally, marked

        tachypnoea (mean 180 cycles/min as against 110 c/min in the conscious

        controls) and raised functional residual capacity were found. A drop in

        the respiration rate and in FRC after bilateral cervical vagotomy

        indicated that a reflex component participates in the origin of the

        above two signs.